Again, this one is a tough one. Ilkay Gundogan would be the obvious choice to continue the role with the absence of Fernandinho. However, like Danilo, he is also one yellow card away from a suspension, and so do you take the risk?
Instead I think you might want Yaya Toure or Fabian Delph in that role. And for me at least, I think I’d prefer Delph. Phil Foden will get the nod also, with David Silva given the night off, and will start alongside Kevin DeBruyne. Although Kevin might get an hour of play in before being substituted.